Barely Significant
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Bridging solvent molecules mediate RNase A - Ligand binding.

PLoS One · 2019 · PMC6808499 · PMID 31644593

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highly significantno p-value reported
Although there are variations in between replicas, the correlations are highly significant in every replica, which indicates that bridging waters are indeed a key determinant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.