Study of twice-weekly injections of Teriparatide by comparing efficacy with once-weekly injections in osteoporosis patients: the TWICE study.

A 104-week clinical study of the 56.5-μg once-weekly regimen confirmed a significant increase in BMD at the radial distal 1/10 site and an increasing trend in BMD at the distal 1/3 and 1/6 sites, which are rich in cortical bone, which suggested that the 56.5-μg once-weekly regimen may have achieved the increase in radial BMD by avoiding cortical porosity [ 8 ].

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