Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features.

In colorectal cancer, the rate of TOP1 CNG has been reported to range from 53 to 84% [ 26 , 27 ]; moreover, in a metastatic setting, a borderline significant association ( p = 0.007) between an increase in the TOP1 CN and an objective response to second-line treatment with irinotecan monotherapy has been reported [ 28 ].

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