A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.

CPT Pharmacometrics Syst Pharmacol · 2019 · PMC6813168 · PMID 31464379

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a slight trendno p-value reported

There is a slight trend toward over‐prediction in exposure for those mAbs with high AC‐SINS score (mAbs 26–28 in Tg32 mouse); however, these mAbs were still correctly categorized as high CL mAbs.

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