According to the newest statistical report from the American Heart Association, the prevalence of coronary heart disease (CHD) has an increasing trend with age and shows a significant difference between women and men [ 49 ], which suggests that CHD is an age-related disease and its prevalence has a gender difference.
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Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta.
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