Rational design of caspase-responsive smart molecular probe for positron emission tomography imaging of drug-induced apoptosis.

Based on the proposed mechanism, microPET imaging with the co-injection of [ 18 F] 1 with 1 and the injection of [ 18 F] 1 alone both showed an increasing trend in the tumor uptake over time regardless of intravenous or intratumoral administration of DOX, and thus the difference between the treated apoptotic tumor and the untreated tumor became more and more obvious.

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