CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation.

BMC Endocr Disord · 2019 · PMC6820957 · PMID 31664995

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highly significantno p-value reported

Among the highly significant terms several were related to the metabolic processes that regulate cholesterol biosynthesis and fatty acid metabolism, which correlates with our experimental findings suggesting that SPRY2 regulates metabolic processes, such as glucose uptake and lipid accumulation.

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