highly significantP =1.59×10 −225
Cytochrome P450 enzymes such as CYP2A7 and CYP2A13 score highly as well, and these genes are implicated in bladder cancer but not normally expressed in breast tissue [ 47 , 48 ]. Results for alternative edge weights w ′ = w /2 are shown in Additional file 1 : Figures S7–S9, again with highly significant differences between real and shuffled edge selections (M–W P =1.59×10 −225 for ROC AUC, P =5.02×10 −213 for nDCG, and P =4.12×10 −181 for Spearman correlation P -values).