Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling.

3 A) are highly significant (Fisher's two-tailed P- value <2.3 × 10 −62 ), whereas for shuffled regions the overlap is decreased to ∼6% and not significant (Fisher's two-tailed P- value>0.059, exact P -values see Supplemental Table S3 ).

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