Barely Significant
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Prolonged fever is not a reason to change antibiotics among patients with uncomplicated community-acquired acute pyelonephritis.

Medicine (Baltimore) · 2019 · PMC6824812 · PMID 31651906

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an increasing trendno p-value reported
Antimicrobial resistance and extended spectrum β-lactamase producing strains had an increasing trend in the non-responder group but there was no significant difference between the groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.