Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection.

Aging Cell · 2019 · PMC6826146 · PMID 31407474

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0.0980

closest p · 2.0× alpha

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a nonsignificant trendp = .098so close (0.05 < p ≤ 0.1)

Further exploring the interaction term (Figure S6 a), participants who currently smoked showed a nonsignificant trend toward lower heteroplasmy while they aged ( p = .098; Figure S6 b), and participants who never smoked had more heteroplasmy as they aged ( p < .001, Figure S6 c).

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