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Long Non-Coding RNA (LncRNA) CAIF is Downregulated in Osteoarthritis and Inhibits LPS-Induced Interleukin 6 (IL-6) Upregulation by Downregulation of MiR-1246.

Med Sci Monit · 2019 · PMC6827483 · PMID 31653823

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an increasing trendno p-value reported
OA affects about 40% of people older than 40 years of age, and the incidence rate shows an increasing trend in recent years.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.