60 , 61 This might be significant as stimulation of the PTEN-PI3K pathway sustains growth, proliferation, invasion, and apoptosis of cancer cells. 62 , 63 Previous evidence indicated that PTEN loss cooperates with a PIK3CA mutation to accelerate progression of CRPC growth, 64 and further research has linked the expression of PTEN with proliferation and apoptosis of PCa cells. 65 Consistent with these results, we observed that knockdown of E2F1 inhibited proliferation and accelerated apoptosis in PC3 cells but not in DU145 cells.
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Key Genes And Pathways Controlled By E2F1 In Human Castration-Resistant Prostate Cancer Cells.
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