Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.

An analysis of this data including patients with FSG ≤ 5 times increased (≤500 pg/mL) in that study ( Figure 2 B) demonstrates that there is a highly significant direct correlation between any increase in FSG and the degree of increase in the ECL proliferative change without any apparent threshold effect.

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