Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice.

We observed an increase in the nuclear, but not the cytoplasmic IHC staining for MAT1A (Mean: 0.966 ± 0.42) compared to those whose prior treatment status was listed as “not reported” (Mean: 0.6468 ± 0.3568) or those previously treated with BCG (Mean: 0.6475 ± 0.454); this difference was not quite significant ( p = 0.0572), likely due to insufficient statistical power from a limited sample size ( Figure 3 C).

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