Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty.

In this process, pathways identified as significant can contain individual metabolites that may not be significant on their own—due to their presence within a pathway that has other significant features contained within it.

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This multi-level approach developed a mROC model that identified 12 metabolites as being highly significant in the differentiation of subjects exhibiting frail and non-frail phenotypes as indicated by their position on the FI.

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