The synergistic effect between hydrogen peroxide and nitrite, two long-lived molecular species from cold atmospheric plasma, triggers tumor cells to induce their own cell death.

The Yates continuity corrected chi-square test was used for the statistical determination of significances (p < 0.01 = significant; p < 0.001 = highly significant). 3 Results 3.1 H 2 O 2 and nitrite interact synergistically in the induction of apoptosis of tumor cells For the evaluation of potential synergistic effects between H 2 O 2 and nitrite or nitrate during apoptosis induction in malignant cells, increasing concentrations of H 2 O 2 were added to human MKN-45 gastric carcinoma cells.

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