Asthma, which places significant stretch stimulus to the chest wall, is a well-known predictor of VOC and interestingly, while nighttime hypoxia during sleep studies did not predict painful VOC, the apnea-hypopnea index that is associated with chest wall stretch came very close to statistical significance for predicting VOC [ 38 ].
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Vaso-Occlusion in Sickle Cell Disease: Is Autonomic Dysregulation of the Microvasculature the Trigger?
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