extremely significantp < 0.001
When compared with indomethacin (IND), another positive drug in the study of anti-inflammatory, antipyretic, and analgesic properties [ 29 , 30 ], compounds 1 , 8 – 10 displayed extremely significant effects on NO inhibition ( p < 0.001), and the activities of compounds 7 , 11 , and 12 were also significantly better than that of IND ( p < 0.01).