These findings may be significant not only because this is the first report of non-nucleoside types of DOT1L inhibitor with the anti-metastatic activity but also because DOT1L may be a potential target for metastatic breast cancer.
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Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer.
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