RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation.

Mol Autism · 2019 · PMC6839145 · PMID 31719968

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highly significantno p-value reported

The top ranked and most highly significant DE gene in both discordant group and case control analyses was IGHG4 —Immunoglobulin heavy constant gamma 4, which in both analyses showed evidence for upregulation in ASC affected compared to unaffected individuals (discordant: logFC = 2.15, FDR = 0.0004, case control: logFC = 2.04, FDR = 0.0973).

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