Barely Significant
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"I need somebody who knows about feet" a qualitative study investigating the lived experiences of conservative treatment for patients with posterior tibial tendon dysfunction.

J Foot Ankle Res · 2019 · PMC6839224 · PMID 31719845

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may be significantno p-value reported
Treatment burden and treatment fatigue may be significant clinical issues for patients with PTTD because it increases a patient’s workload of healthcare which may result in non-concordance to treatment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.