Linking Dysregulated AMPK Signaling and ER Stress in Ethanol-Induced Liver Injury in Hepatic Alcohol Dehydrogenase Deficient Deer Mice.

An increasing trend of BAC with an increasing dose of EtOH, as found in both strains, shows dose dependency, but an about two-fold greater BAC and liver injury with significant steatosis in ADH − versus ADH + deer mice fed 3.5% EtOH, suggests a significant role of hepatic class I ADH in EtOH-induced liver injury.

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