Using Structural Analysis <i>In Silico</i> to Assess the Impact of Missense Variants in MEN1.

Analysis of 27 benign and 23 pathogenic variants co-occurring at 22 residues again showed that the difference between the two groups was highly significant ( P = 0.0002) and that, as a group, pathogenic missense changes were more strongly destabilizing than benign ones at the same position (average ΔΔG value by group = 6.81 and 2.18 kcal/mol, respectively) [ Fig. 3(c )].

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