Obesity-linked suppression of membrane-bound <i>O</i>-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

In chow fed mice Mboat7 knockdown only modestly decreased hepatic LPIAT activity toward 18:1 LPI ( Figure 6A ), yet in high fat diet-challenged mice Mboat7 knockdown resulted in a highly significant ~50% reduction in LPIAT activity using either 16:0, 18:0, or 18:1 LPI substrates ( Figure 6A ).

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