Barely Significant
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The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis.

Nat Commun · 2019 · PMC6853988 · PMID 31723143

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The sentences

highly significantP = 2.2e-16actually significant
The rescue of genes found differentially expressed in ∆ Firre CLPs by a Firre transgene produced a highly significant result ( P = 2.2e-16, Fisher exact test); however, we note that the widespread changes in gene expression observed in the CLPs from animals only expressing transgenic Firre RNA could also formally contribute to this effect.

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