Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis.

One possibility is that the differences observed here, although significantly different statistically, may not be significant biologically given the low absolute levels of cytokines measured, although the levels we detected are similar to previous reports (Dandona et al., 1998 ; Kern, Ranganathan, Li, Wood, & Ranganathan, 2001 ; Vozarova et al., 2001 ).

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