Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy.

As can be seen in Figure 1 D, the enzyme activity displayed a decreasing trend during the modification process, and the PEGylated nCAT retained 45% and 39% of its initial catalytic activity at physiological pH of 7.4 and tumor acidic pH of 6.5, rspectively.

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