Barely Significant
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Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.

J Antimicrob Chemother · 2019 · PMC6857193 · PMID 31430369

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may be significantno p-value reported
The high levels of pre-existing resistance observed in these studies, which were designed to minimize pre-existing resistance, indicate that there may be significant underlying resistance among patients with HIV-1 RNA suppression, including those recently infected.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.