No direct association was detected between the low-frequency WBC trait-associated SNPs and ALL risk; however, we found marginally significant synergistic interaction between ALL-associated SNP rs2836371 and three perfectly linked WBC trait SNPs (rs80109907, rs7275212, and rs58030288) on ALL risk in Latinos ( P = 0.079, OR = 2.00) but not in non-Latino whites ( P = 0.48, OR = 0.78) (Supplementary Table S4 ), suggesting Latino-specific cooperation between these two independent trait-associated loci in ALL predisposition.
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Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome.
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