Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage.

Another relevant DEG, TMEM150C (Transmembrane Protein 150C), showed a delayed over-expression, undetectable at the first time point of analysis, but highly significant in the later ones, regardless of the presence of lysozyme in the cell culture medium ( Figure 2 ).

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The regulatory network built with the IPA ® was based on CKMT2 and DLG2 as hinge points because of their extremely significant fold change values and the persistence of their alteration at 1 h and up to 24 h.

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