Overcoming drug resistance may be significant to improve prognosis and survival rates of liver cancer. 5-FU has been demonstrated to irreversibly inhibit thymidylate synthase and act as an antimetabolite, resulting in defection of DNA and RNA synthesis, and thus inducing apoptosis and inhibiting cell growth ( 23 ).
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Claudin-1 silencing increases sensitivity of liver cancer HepG2 cells to 5-fluorouracil by inhibiting autophagy.
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