Barely Significant
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DPYD*6 plays an important role in fluoropyrimidine toxicity in addition to DPYD*2A and c.2846A>T: a comprehensive analysis in 1254 patients.

Pharmacogenomics J · 2019 · PMC6867961 · PMID 30723313

Europe PMCDOI
1
hedged sentence
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

a positive trendp = 0.06so close (0.05 < p ≤ 0.1)
Univariate analysis allowed the selection of c.1905+1G>A, c.2194G>A and c.2846A>T alleles as significantly associated with gastrointestinal and hematological ADRs ( p < 0.05), while the c.496A>G variant showed a positive trend of association with neutropenia ( p = 0.06).

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