Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma.

Diagnostic scores and additional clinical characteristics Overall, the wd-scores showed an increasing trend from controls to HCC, noting the significantly higher scores in patients with early HCC than in subjects with CHB/LC or controls in the training set and validation set 1 (Wilcoxon rank-sum test p<0.001, figure 5C ).

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