Reply to Hedrick and Klitz: High haplotype discovery rate in the HLA locus.

Proc Natl Acad Sci U S A · 2019 · PMC6876207 · PMID 31662470

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highly significantno p-value reported

Analysis of haplotypes reveals the opposite trend, with a highly significant excess of haplotype homozygotes, as computed from the frequency distribution assuming Hardy–Weinberg equilibrium, or from the estimate of haplotype pairs in genotypes ( 1 , 2 ); thus, all classical measures of support purifying selection at the level of haplotypes.

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