Effect of Parkinson's disease and related medications on the composition of the fecal bacterial microbiota.

NPJ Parkinsons Dis · 2019 · PMC6884491 · PMID 31815177

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borderline significanceno p-value reported

PD patients treated with L-dopa showed a borderline significance ( p Observed = 0.05) for the abundance of predicted pathways when compared to the control group.

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borderline significantno p-value reported

Previous studies found a borderline significant influence of L-dopa on the total gut microbiome or discussed the treatment with L-dopa as a possible influencing factor. 14 , 22 , 32 Furthermore, a recent study showed the important role of microbial metabolism in drug availability and degradation in the gut. 20 However, as far as we know, no study specifically addressed changes in microbial community composition in PD related to L-dopa medication in detail.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.