The analysis of severe exacerbations alone showed a similar pattern, with a nonsignificant trend towards increased exacerbations for LABA/ICS in the low eosinophil stratum (HR 1.14 (95% CI 0.88–1.46) but a significant reduction in the high eosinophil stratum with an HR of 0.67 (95% CI 0.48–0.92).
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