MicroRNA-binding site polymorphisms and risk of colorectal cancer: A systematic review and meta-analysis.

For rs731236 in overall meta‐analysis (based on minor allele; t) no significant result for the risk of CRC was observed, but in subgroup analysis in Middle East population the results were significant in heterozygote (Tt vs TT) (0.76 [0.61‐0.95]) and overdominant models (Tt vs TT + tt) (0.75 [0.61‐0.92]), and borderline significance was observed in dominant model (tt + Tt vs TT) (0.81 [0.66‐1.00]) (Figure 2 , Figure S2 ).

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In East Asian population, the allelic model (T vs C) (1.25 [1.01‐1.54]) significantly increased the risk of CRC and in dominant model (TT + TC vs CC) (1.29 [1.00‐1.66]) there was a trend towards significance (Figure 3 , Figure S3 ).

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