Interestingly, the percentage of AR and ERG peaks that physically colocalized in ERG mouse prostates was ~ 44%, which is highly significant, yet new AR peaks, those that did not exist in WT mice, had less overlap with ERG peaks than did the conserved AR peaks (~ 40% compared to ~ 60%) making it unlikely that ERG directly recruits the AR to new sites.
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Factors that influence the androgen receptor cistrome in benign and malignant prostate cells.
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