Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cells.

This network also reveals essential nodes and highly significant correlations were detected among their basic topological parameters as follows: nodes/k (R: 0.913, R 2 : 0.770); neighbors/BC (R: 0.999, R 2 : 0.926) and neighbors/CC (R: 0.807, R 2 : 0.695) [ Fig. 1 C], and only two essential nodes, TP53 and CASP3, associated to the intrinsic apoptosis, seems to be involved in the information processing of the network [ Fig. 1 D].

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