Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.

Our results showed a significant excess of nonsynonymous variants ( P = 0.047) in the Kinh population from Vietnam and a borderline significant excess of amino acid variation (0.1 ≥ P ≥ 0.05) in other populations of African (African Americans and the Mende), South Asian (Bengali, Gujarati, Telugu, Punjabi and Sri Lankan Tamil), European (Finnish, Great British, and Iberian), and East Asian (Dai and southern Han Chinese) ancestry (Table 1 ).

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Lastly, we detected a significant and marginally significant excess of nonsynonymous polymorphisms in African and non-African populations.

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