Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics.

BMC Med · 2019 · PMC6892209 · PMID 31796040

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

marginally statistically significantp = 0.058so close (0.05 < p ≤ 0.1)

After removing two potential outliers (i.e., rs12219514 and rs75536691), however, the causal effect of T2D on ALS becomes stronger and marginally statistically significant (OR = 1.28, 95% CI 0.99–1.62, p = 0.058) (Fig. 3 a), suggesting that T2D may increase the risk of ALS in the East Asian population.

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