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Investigating the Comparative Effects of Six Artemisinin-based Combination Therapies on <i>Plasmodium</i>-induced Hepatorenal Toxicity.

Niger Med J · 2019 · PMC6892336 · PMID 31831942

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a decreasing trendno p-value reported
Collectively, this study shows a decreasing trend following ACT administration on the serum urea levels compared to NC which correlates with previous studies, but an increase in urea level following AM administration in a nonmalarial study has been reported. 58 There was no significant change in creatinine level in the treated groups compared to NC (0.62 mg/g), but AM had the widest variation in concentration (0.74 mg/g).

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