L-DOPA improves extinction memory retrieval after successful fear extinction.

In contrast, in participants with non-successful extinction (high CR at the end of extinction: (SCR CS+ > CS-) > 0); n = 42), there was no significant effect of drug administration, but there was a weak trend towards greater CRs at test after L-DOPA compared to placebo administration (Fig. 3c ; stim: F (1,40) = 36.97, p < .001, partial η 2 = .48; stim*group: F (1,40) = 2.85, p = .099), indicating that L-DOPA administration after non-successful extinction may even have detrimental effects on long-term expression of fear.

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