Sex and Individual Differences in Alcohol Intake Are Associated with Differences in Ketamine Self-Administration Behaviors and Nucleus Accumbens Dendritic Spine Density.

High-alcohol intake female rats in the ketamine group were significantly higher than saline in the second PR session only, and a statistical trend toward significance was noted in the third session (SA session 8–9: t (47) = 3.67, 1.89; p = 0.0006, 0.06, respectively; Fig. 3 a , b ).

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