Incidence rates of immune-related adverse events and their correlation with response in advanced solid tumours treated with NIVO or NIVO+IPI: a systematic review and meta-analysis.

J Immunother Cancer · 2019 · PMC6894272 · PMID 31801636

Europe PMC DOI

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0.1100

closest p · 2.2× alpha

0.1100

boldest claim

The sentences

borderline significanceP = 0.11not close (p > 0.1)

Borderline significance was also observed in endocrine irAEs (r = 0.44, P = 0.11) and hepatic irAEs (r = 0.55, P = 0.05) (Fig. 5 ).

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borderline significantno p-value reported

For NIVO, the correlation between ORR and the incidence rates of skin, gastrointestinal or endocrine irAEs remained significant or borderline significant in all the sensitivity analysis (Additional file 1 : Table S3), further confirming the clinical value of these irAEs.

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