Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis.

Using the mentioned macronutrients and questionnaire derived intake variables as covariates in the analysis of disease‐associated shifts in microbial beta‐diversity yielded no significant associations ( P > 0.05, respectively) and also revealed only minor effects on the still highly significant change in community composition associated with PSC ( P = 0.003, R 2 = 0.019). 4 DISCUSSION It is unclear, to which extent reported single centre microbiota studies in PSC were influenced by environmental factors and whether reported associations would remain significant across different geographical regions.

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