Does the evidence support the importance of high transfusion ratios of plasma and platelets to red blood cells in improving outcomes in severely injured patients: a systematic review and meta-analyses.

Laboratory measures of coagulopathy were reported in a few studies and reported inconsistent results, however, demonstrating an overall trend to improvement of coagulation tests.

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ROTEM variables were assessed in a single study 37 that showed a nonsignificant trend in the proportion of patients developing coagulopathy according to the number of RBC units transfused (40% on admission, 58% after 4 units of RBCs, and 81% after 8 units of RBCs), as measured by clotting amplitude at 5 minutes.

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