Increased lifespan, decreased mortality, and delayed cognitive decline in osteoarthritis.

In terms of AMRT, the cohorts with 2 and 3 osteoarthritic body sites statistically differ from that with no arthritis or with one body site affected by OA, while the differences between “OA in 2 body sites” and “OA in 3 body sites” as wells as “no arthritis” and “one body site osteoarthritis” fell short of significance (p = 0.44 for “OA in 2 body sites” vs. “OA in 3 body sites”; p = 0.29 for “no OA” vs “OA in 1 body site”, p = 6.4 × 10 −8 for “no OA” vs “OA in 3 body sites”, p = 1 × 10 −5 for “OA in 1 body site” vs “OA in 3 body sites”, p = 2.7 × 10 −7 for “no OA” vs “OA in 2 body sites”, Fig. 5C ).

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