Transcriptome Analysis Identifies Immune Markers Related to Visceral Leishmaniasis Establishment in the Experimental Model of BALB/c Mice.

Specifically, an increasing trend that did not reach significance in the percentage of intracellular IFN-γ was detected in CD4 + T cells with the higher percentage of intracellular IFN-γ detected within CD8 + T cells from mice vaccinated with CPA 160−189 -loaded p8-PLGA nanoparticles as compared to PBS- and p8-PLGA nanoparticle-vaccinated mice ( p < 0.001 and p < 0.05, respectively) ( Figures 2G,H ).

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The PPI network consisting of 271 nodes that interacted with 729 edges and an enrichment p < 1.0e − 16, identified a highly significant enrichment for “immune system” (MMU-168256; FDR 1.39E-24), “innate immune system” (MMU-168249; FDR 5.39E-22) and “neutrophil degranulation” (MMU-6798695; FDR 8.81E-18) ( Figure 7 ) further verifying the above analysis.

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